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Nitrous oxide has long been used as an analgesia in dentistry, and there has been a recent resurgence of interest in using it in obstetrics as well. This guide offers practical, easy-to-follow advice for midwives and anyone else involved in childbirth who wants to add nitrous oxide to their pain management toolbox. The guide not only covers the practical steps that need to be taken for nitrous oxide to be used safely and effectively in a variety of practice environments, but it also offers suggestions for how to engage all relevant stakeholders, respond to the myths surrounding nitrous oxide use, and allay concerns that will inevitably arise.